Abstract #1793

White matter neuroplasticity: Motor learning modifies hemodynamic responses in the internal capsule

Lukas A. Grajauskas^1,2,3, Tory Frizzell^2,4, Sujoy Hajra^2,4, Caressa Liu^2,4, Xiaowei Song^2,3, and Ryan C.N. D'Arcy^4,5

¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Surrey Memorial Hospital ImageTech Laboratory, Fraser Health, Surrey, BC, Canada, ³Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada, ⁴Faculty of Applied Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁵Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada

Though white matter has a noted role in motor learning, there have been no MRI studies of functional neuroplasticity in this tissue. Therefore, in this work, twelve healthy participants underwent a motor training program designed to drive behavioral changes in the non-dominant hand. Using BOLD fMRI, we noted an associated change in the temporal dispersion of the white matter hemodynamic response over the training period. This is in line with previous DTI studies that show increases in white matter myelination with training, and BOLD investigations that show hemodynamic responses differ between grey and white matter, and between white matter tracts.

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