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Abstract #1803

Assessing gray and white matter glutamatergic turnover in human brain non-invasively using 1H MRS and deuterated glucose

Puneet Bagga1, Laurie J Rich1, Abigail Cember1, Ravi Prakash Reddy Nanga1, Deepa Thakuri1, Mark Elliott1, Mohammad Haris2,3, John A Detre4, and Ravinder Reddy1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Sidra Medicine, Doha, Qatar, 3LARC, Qatar University, Doha, Qatar, 4Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Cerebral metabolism is reported to be monitored by various techniques including 13C/2H MR spectroscopy and 18F-FDG Positron emission tomography. It is well known that 1H MRS allows the non-invasive detection and quantification of neurochemicals. In this study, we performed 1H MRS in conjuction with the oral administration of [6,6′-2H2]glucose in a healthy volunteer at 3T and 7T to measure turnover of glutamate in gray and white matter. As 2H is invisible on 1H MRS, the 2H enrichment of glutamate leads to a corresponding drop in its 1H MR resonance measured via LCModel.

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