Abstract #1803

Assessing gray and white matter glutamatergic turnover in human brain non-invasively using 1H MRS and deuterated glucose

Puneet Bagga¹, Laurie J Rich¹, Abigail Cember¹, Ravi Prakash Reddy Nanga¹, Deepa Thakuri¹, Mark Elliott¹, Mohammad Haris^2,3, John A Detre⁴, and Ravinder Reddy¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Sidra Medicine, Doha, Qatar, ³LARC, Qatar University, Doha, Qatar, ⁴Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Cerebral metabolism is reported to be monitored by various techniques including ¹³C/²H MR spectroscopy and ¹⁸F-FDG Positron emission tomography. It is well known that ¹H MRS allows the non-invasive detection and quantification of neurochemicals. In this study, we performed ¹H MRS in conjuction with the oral administration of [6,6′-²H₂]glucose in a healthy volunteer at 3T and 7T to measure turnover of glutamate in gray and white matter. As ²H is invisible on ¹H MRS, the ²H enrichment of glutamate leads to a corresponding drop in its ¹H MR resonance measured via LCModel.

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