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Abstract #1871

Realistic MRI simulation pipeline for anatomically variable normal young, aging and diseased brain

Aymen Ayaz1, Jouke Smink2, Tom Geraedts3, Cristian Lorenz4, Juergen Weese4, and Marcel Breeuwer1,2
1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2MR R&D – Clinical Science, Philips Healthcare, Best, Netherlands, 3MR R&D – Collaboration Office, Philips Healthcare, Best, Netherlands, 4Philips Research Laboratories, Hamburg, Germany

A pipeline based on the XCAT phantom, the JEMRIS software for simulating the MR signal and a commercial reconstruction pipeline has been set-up for simulating realistic brain MRI images. Using this pipeline, an anatomically variable brain MRI population is simulated across age and gender. Anatomical variation is generated by means of changing individual brain sizes, and cortical gray matter volumes to mimic aging brain. MS lesions are simulated to mimic diseased brain as well. Significant contrast is generated across detailed brain structures. The commercial reconstruction pipeline increased the realism of simulated data.

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