Abstract #1875

The moderation effects of depression and anxiety on sleep-linked cortical morphology in general population

Yanlin Wang¹, Ping Jiang¹, Shi Tang¹, Lu Lu¹, Xuan Bu¹, Hailong Li¹, Yingxue Gao¹, Lianqing Zhang¹, Lingxiao Cao¹, Jing Liu¹, Xinyue Hu¹, Xinyu Hu¹, Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China

It remains unclear whether cortical changes in poor sleep quality are modulated by emotional distress in the general population. An Elastic-Net Regularized Generalized Linear Models based on bootstrapping was implemented to acquire candidate regions for sleep quality. The moderation effects of emotional distress on the relationship between sleep quality and cortical morphometry were acquired by a hierarchical regression. The low level of emotional distress could offset positive correlation between sleep quality and dorsal anterior cingulate cortex (dACC) volume. The result indicates dACC volume enlargement might be a compensatory response to poor sleep quality, or a marker of resilience against recurrent emotional distress.

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