A subset of nonfunctioning pituitary macroadenomas (NFMAs) show early progression/recurrence (P/R) after surgery. In clinical practice, one of the main challenges in the treatment of NFMAs is to determine factors that correlate with P/R. This study investigated the role of radiomics for the prediction of P/R in NFMAs. 50 patients diagnosed with benign NFMAs were studied. Totally 214 descriptors were extracted from the various MR sequences. The prediction accuracy of P/R was 82% and the AUC of the prediction model was 0.78.