High grade supratentorial ependymomas in adults are rare neoplasms with imaging features that can often be confused for high grade gliomas. However, the pathogenesis of ependymoma’s differs significantly and it therefore crucial to determine pre-operative non-invasive markers for treatment planning and optimization. Our work creates a multi-variate 3-way classification framework based on multimodal MRI radiomics to discriminate supra-tentorial ependymomas, grade III and IV gliomas. Results demonstrate high accuracy with specific textures that evolve as the top discriminative features and can be pursued for clinical applicability.
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