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Abstract #1918

Detecting Synaptic Dysfunction caused by Pathological α-Synuclein Accumulation in Mouse Brain using MRS

Yuhei Takado1, Maiko Ono2, Keiichiro Minatohara2, Masafumi Shimojo2, Nobuhiro Nitta2, Sayaka Shibata2, Naruhiko Sahara2, Ichio Aoki2, Masato Hasegawa3, and Makoto Higuchi2
1Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 3Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

To develop therapeutic strategies, in vivo detection of the early pathological changes in Parkinson’s disease is critically important. In this work, we aimed to detect early pathological changes caused by the propagation of α-synuclein in mouse brain using MRS. Recombinant α-synuclein and fibrils were prepared and injected into C57BL6 mice. 8 weeks after the injection, glutamate levels were decreased significantly compared to saline-injected control mice, which was in accordance with decreased synapsin staining in the cortex. We demonstrated that MRS can detect synaptic dysfunction caused by α-synuclein propagation in vivo.

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