Abstract #1918

Detecting Synaptic Dysfunction caused by Pathological α-Synuclein Accumulation in Mouse Brain using MRS

Yuhei Takado¹, Maiko Ono², Keiichiro Minatohara², Masafumi Shimojo², Nobuhiro Nitta², Sayaka Shibata², Naruhiko Sahara², Ichio Aoki², Masato Hasegawa³, and Makoto Higuchi²

¹Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ³Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

To develop therapeutic strategies, in vivo detection of the early pathological changes in Parkinson’s disease is critically important. In this work, we aimed to detect early pathological changes caused by the propagation of α-synuclein in mouse brain using MRS. Recombinant α-synuclein and fibrils were prepared and injected into C57BL6 mice. 8 weeks after the injection, glutamate levels were decreased significantly compared to saline-injected control mice, which was in accordance with decreased synapsin staining in the cortex. We demonstrated that MRS can detect synaptic dysfunction caused by α-synuclein propagation in vivo.

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