Abstract #2001

Hippocampus subfield segmentation reliability is improved by non-linear realignments between scan-repetitions at 7T and 3T.

Thomas B Shaw¹, Steffen Bollmann¹, Nicole T Atcheson¹, Lachlan T Strike¹, Christine Guo², Katie L McMahon³, Jurgen Fripp⁴, Margaret J Wright¹, Olivier Salvado^4,5, and Markus Barth¹

¹The University of Queensland, Brisbane, Australia, ²QIMR Berghofer Medical Research Intstitute, Brisbane, Australia, ³Queensland University of Technology, Brisbane, Australia, ⁴CSIRO Health and Biosecurity, Brisbane, Australia, ⁵CSIRO Data61, Sydney, Australia

MR image quality is affected greatly by participant movement. Anatomical image quality can be improved by acquiring consecutive anatomical scans and combining them to boost SNR and sharpness. We aimed to find the optimal combination method of three repetitions of high-resolution turbo spin-echo (TSE) scans, commonly used for hippocampus subfield segmentation. We used non-linear realignment between the TSE repetitions in a range of participants at 3T and 7T and found that image segmentation reliability and sharpness were higher for the non-linear realignment technique, as compared to linearly realigned, and averaged methods. Hippocampus image segmentation greatly benefits from this technique.

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