Abstract #2030

Quantification of contrast enhancement from FLAIR to assess meningeal inflammation in a meningoencephalitis model

Ji Hyun Lee¹, Jeffrey Solomon^1,2, Donna Perry¹, Jennifer Sword¹, Marcelo Castro¹, Joseph Laux¹, Rebecca Reeder¹, Yu Cong¹, Ian Crozier^1,2, Irwin M Feuerstein¹, and Dima Hammoud³

¹Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, Frederick, MD, United States, ²Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, United States, ³Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States

The purpose of this study was to utilize advanced post processing analysis to assess the degree of meningeal inflammation in an animal model of Lassa virus induced meningoencephalitis. Subtraction analysis of co-registered pre- and post-contrast FLAIR images revealed various degrees of meningeal inflammation between animals. Histopathology confirmed viral meningoencephalitis. This approach can be helpful in detecting mild to severe degrees of meningeal inflammation in a variety of infectious diseases.

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