Mesial Temporal Lobe Epilepsy (MTLE), the most common form of adult-onset epilepsy, represents a convenient candidate to study brain structural covariance networks. In particular, mild MTLE is a precious resource to study brain structure and function independently from the damage caused by seizure recurrence and medication use. In this work, we used graph analysis to investigate structural covariance networks in mild and refractory MTLE, and found that while the latter shows altered integration and segregation network properties, mMTLE has graph-based characteristics suggestive of a possibly inborn different brain organization that might act as protective factor against seizure recurrence.
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