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Abstract #2048

Magnetization Transfer Contribution to Balanced SSFP Image Contrast in Chronic Myocardial Infarction

Xinheng Zhang1,2, Hsin-Jung Yang2, Richard Tang2, and Rohan Dharmakumar2,3
1Bioengineering Department, University of California, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Department of Medicine, University of California, Los Angeles, CA, United States

Magnetization Transfer (MT) effect in balanced steady-state free precession (bSSFP) has been demonstrated in acute myocardial infarction (MI). However, whether MT effect influences image contrast in bSSFP acquisitions of chronic MI has not been investigated. We studied this using a collagen phantom and large animal models with chronic MI. We found the bSSFP MT ratio to be more than 2-fold higher in the chronic MI zone compared to uninfarcted myocardium. Our findings support the notion that a strong MT contrast in bSSFP acquisitions, likely from collagen deposition within chronic MI, is available for discriminating chronic MI territories without contrast agents.

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