Abstract #2050

Sensitivity of Cardiac Diffusion Encoding Waveforms to Myocardial Extracellular Volume: A simulation study

Kevin Moulin¹, Magalie Viallon², Nyasha Maforo^3,4, Valentina Mazzoli¹, Pierre Croisille², and Daniel Ennis^1,5,6

¹Department of Radiological Sciences, Stanford University, Stanford, CA, United States, ²Université de Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint Etienne, France, ³Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁴Physics and Biology in Medicine Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, United States, ⁵Division of Radiology, Veteran Affairs Health Care System, Palo Alto, CA, United States, ⁶Cardiovascular Institute, Stanford University, Palo Alto, CA, United States

In vivo cardiac DWI is sensitive to cardiac bulk motion and requires second-order motion compensated gradient designs. Even for a fixed b-value, motion and non-motion compensated diffusion encoding gradient waveforms have different lobe durations, number of encoding lobes, and diffusion encoding times (Δ). It remains unclear if these gradient waveforms have the same sensitivity to intra- and extra-cellular diffusion and to ECV changes. The objective of this work was to analyze the sensitivity of various gradient waveforms (fixed b-value) to a change in ECV by simulating molecular displacements in a two-compartment model.

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