Abstract #2075

Right ventricular T1-mapping in boys with Duchenne muscular dystrophy and healthy controls at 3T

Seraina A. Dual^1,2, Nyasha G. Maforo^3,4, Patrick Magrath^1,5, Doff B. McElHinney⁶, Ashley Prosper⁵, Holden H. Wu^4,5, Nancy Halnon⁷, Shiraz Maskatia^6,8, Pierangelo Renella^3,5, and Daniel B. Ennis^1,8,9

¹Department of Radiology, Stanford University, Palo Alto, CA, United States, ²Department of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, United States, ³Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, CA, United States, ⁴Department of Radiological Sciences, University of California, Los Angeles, CA, United States, ⁵Department of Bioengineering, University of California, Los Angeles, CA, United States, ⁶Department of Pediatrics, Stanford University, Palo Alto, CA, United States, ⁷Department of Pediatrics, University of California, Los Angeles, CA, United States, ⁸Maternal & Child Health Research Insitute, Palo Alto, CA, United States, ⁹Cardiovascular Insitute, Stanford University, Palo Alto, CA, United States

Early diagnosis of cardiac involvement in boys with Duchenne muscular dystrophy (DMD) allows for timely therapy. The aim of this study was to assess the association between native T1 in the right ventricle (RV) and cardiac involvement as marked by decreased left ventricular (LV) or RV ejection fraction (EF). Healthy boys (N=10) and boys with DMD (N=16) underwent 3T cardiac MR using motion-corrected gradient-MOLLI T1-mapping, a clinically routine protocol. RV-T1 did not correlate with LVEF or RVEF. Longer native LV-T1 was associated with lower LVEF. Based on this data, native RV-T1 does not provide insight to cardiac involvement in DMD.

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