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Abstract #2075

Right ventricular T1-mapping in boys with Duchenne muscular dystrophy and healthy controls at 3T

Seraina A. Dual1,2, Nyasha G. Maforo3,4, Patrick Magrath1,5, Doff B. McElHinney6, Ashley Prosper5, Holden H. Wu4,5, Nancy Halnon7, Shiraz Maskatia6,8, Pierangelo Renella3,5, and Daniel B. Ennis1,8,9
1Department of Radiology, Stanford University, Palo Alto, CA, United States, 2Department of Cardiothoracic Surgery, Stanford University, Palo Alto, CA, United States, 3Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, CA, United States, 4Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 5Department of Bioengineering, University of California, Los Angeles, CA, United States, 6Department of Pediatrics, Stanford University, Palo Alto, CA, United States, 7Department of Pediatrics, University of California, Los Angeles, CA, United States, 8Maternal & Child Health Research Insitute, Palo Alto, CA, United States, 9Cardiovascular Insitute, Stanford University, Palo Alto, CA, United States

Early diagnosis of cardiac involvement in boys with Duchenne muscular dystrophy (DMD) allows for timely therapy. The aim of this study was to assess the association between native T1 in the right ventricle (RV) and cardiac involvement as marked by decreased left ventricular (LV) or RV ejection fraction (EF). Healthy boys (N=10) and boys with DMD (N=16) underwent 3T cardiac MR using motion-corrected gradient-MOLLI T1-mapping, a clinically routine protocol. RV-T1 did not correlate with LVEF or RVEF. Longer native LV-T1 was associated with lower LVEF. Based on this data, native RV-T1 does not provide insight to cardiac involvement in DMD.

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