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Abstract #2106

Pulse wave velocity and wall shear stress in the carotid arteries of familial hypercholesterolemia patients

Eva S Peper1, Ilse K Luirink2, Pim van Ooij1, Bram F Coolen3, Gustav J Strijkers3, Albert Wiegman2, Barbara A Hutten4, and Aart J Nederveen1
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Department of Paediatrics, Amsterdam UMC, Amsterdam, Netherlands, 3Department of Physics and Biomedical Engineering, Amsterdam UMC, Amsterdam, Netherlands, 4Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands

Familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein (LDL) cholesterol levels form birth onwards and premature cardiovascular disease. Statins are currently the preferred pharmacological therapy. Results from a recent study suggest that initiation of lipid-lowering treatment during childhood reduces the risk for cardiovascular disease in adulthood. With advanced acquisition strategies of 2D and 4D flow MRI we investigated PWV and WSS in the carotid arteries of 43 FH patients and 18 healthy controls of a similar age (33 years), as PWV and WSS have both been associated with atherosclerosis.

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