Familial hypercholesterolemia (FH) is characterized by elevated low-density lipoprotein (LDL) cholesterol levels form birth onwards and premature cardiovascular disease. Statins are currently the preferred pharmacological therapy. Results from a recent study suggest that initiation of lipid-lowering treatment during childhood reduces the risk for cardiovascular disease in adulthood. With advanced acquisition strategies of 2D and 4D flow MRI we investigated PWV and WSS in the carotid arteries of 43 FH patients and 18 healthy controls of a similar age (33 years), as PWV and WSS have both been associated with atherosclerosis.
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