Abstract #2170

Association Between Physical Activity and Left Ventricular Diastolic Function and Morphology assessed by MRI in Obesity

Hugo Klarenberg¹, Jeroen H. P. M. van der Velde², Ilona A. Dekkers³, R. de Mutsert², J. Wouter Jukema⁴, Frits R. Rosendaal², Mark Gosselink⁵, Martijn Froeling⁵, Gustav J. Strijkers¹, S. Matthijs Boekholdt⁶, and Hildo J. Lamb³

¹Biomedical Engineering and Physics, Amsterdam UMC location AMC, Amsterdam, Netherlands, ²Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Department of Cardiology, Amsterdam UMC location AMC, Amsterdam, Netherlands

Heart failure with preserved ejection fraction is accompanied by diastolic dysfunction. Diastolic dysfunction is associated with metabolic dysregulations, particularly obesity. Physical Activity might reduce this process improving diastolic function and left ventricular (LV) morphology. In this cross-sectional Netherlands Epidemiology of Obesity study, individuals underwent cardiovascular MRI to asses diastolic function and LV Morphology. Physical Activity was determined via the SQUASH questionnaire. Multivariable linear regression was performed adjusting for metabolic covariates. Physical Activity was moderately associated to diastolic function and strongly to LV Morphology. Conclusively, associations of diastolic function and LV morphology with Physical Activity can be determined accurately by MRI.

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