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Abstract #2187

Cardiac MRI for identifying radiation therapy effect on the heart

El-Sayed H Ibrahim1, Dhiraj Baruah1, Pierre Croisille2, Jadranka Stojanovska3, Jason Rubenstein1, Rachel Schlaak1, Anne Frei1, Elizabeth Gore1, and Carmen Bergom1
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Jean-Monnet University, Lyon, France, 3University of Michigan, Ann Arbor, MI, United States

Lung cancer is the most frequently diagnosed cancer worldwide. Radiation therapy (RT) is standard-of-care in one-third of the patients, where the incidence of cardiac complications in lung cancer patients after RT reaches 33%. The current paradigm for cardiotoxicity detection and management relies primarily upon assessment of ejection fraction (EF). However, cardiac injury can occur without a clear change in EF. In this study, we investigate the effect of RT on global and regional cardiac function and myocardial T1/T2 values. The results show the capability of regional cardiac MRI for depicting early changes in myocardial contractility pattern and tissue characterization post-RT.

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