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Abstract #2195

Relationships between CMR, rheometry and Raman spectroscopy of doxorubicin induced cardiotoxicity in the swine.

Delphine Perie1, Eric Buzaglo1, Clemence Balosetti1, Helene Heon2, and Daniel Curnier3
1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Research Center, CHUM, Montreal, QC, Canada, 3Kinesiology, University of Montreal, Montreal, QC, Canada

CMR has already been used to investigate the long term effects of cancer treatments. We investigated relationships between clinical, CMR, mechanical and biochemical properties of the myocardium and their changes due to early doxorubicin induced cardiotoxicity in the swine model. MR relaxation times and CMR function parameters highlighted the importance of regional analysis because of the heterogeneity in the tissue response to doxorubicin treatment. The observation of different remodelling patterns between moving and fixed cardiac walls needs to be translated to personalized diagnosis and medicine approaches for cancer treatment application.

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