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Abstract #2248

Vascular Imaging of the Human Kidney with Positive Contrast via SPION and UTE

Liam Timms1, Tianyi Zhou1, Ju Qiao2, Vishala Mishra3, Gayatri Veeramani4,5, Andrew Allegretti4, Thomas Benkert6, John Kirsch2, Ravi Seethamraju7, Mukesh Harisinghani3, and Srinivas Sridhar1,8
1Physics, Northeastern University, Boston, MA, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Radiology, Massachusetts General Hospital, Boston, MA, United States, 4Nephrology, Massachusetts General Hospital, Boston, MA, United States, 5Nephrology, Brigham and Women’s Hospital, Boston, MA, United States, 6Siemens Healthcare, Erlangen, Germany, 7Siemens Healthcare, Boston, MA, United States, 8Theranano LLC, Newton, MA, United States

A contrast-enhanced MRA technique using Ultra-short Time-to-Echo (UTE) pulse sequence with super-paramagnetic iron oxide nanoparticle (SPION) contrast agent is demonstrated for abdominal vascular imaging in human patients. It successfully depicts the kidney anatomy, as well as kidney cysts and kidney vascular structure in excellent clarity and detail. With manual segmentation, total kidney volume, cyst volume and renal artery diameter were estimated. This initial study in humans demonstrated the basic feasibility of abdominal QUTE-CE MRA as an alternative to Gd based CEMRA.

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