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Abstract #2262

Feasibility of a Free-Breathing 2D Phase Contrast Sequence for Aortic Pulse Wave Velocity Measurements

Grant S Roberts1, Kevin M Johnson1,2, Steven R Kecskemeti2, Ozioma Okonkwo3, Sarah Lose3, Laura Eisenmenger2, and Oliver Wieben1,2
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Medicine, University of Wisconsin - Madison, Madison, WI, United States

Pulse wave velocity (PWV) is a biomarker that indirectly relates to arterial stiffness, an early indicator of cardiovascular disease. Breath-hold phase contrast (PC) MRI can be used to assess PWV in the aorta, however in certain populations, breath-holds may be difficult. We present a method to measure aortic PWV using a free-breathing radially-undersampled PC sequence. Initial results show that the free-breathing PC-derived PWV measures are comparable to the measures obtained from breath-hold Cartesian PC scans. Larger cohorts are warranted to verify these findings.

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