Abstract #2309

Free breathing 1H MRI Specific Ventilation: Sensitivity to Bronchodilator and Airway Dysfunction in Severe Asthma

Dante PI Capaldi¹, Norman B Konyer², Melanie Kjarsgaard³, Michael D Noseworthy^2,4, Parameswaran Nair^3,5, and Sarah Svenningsen^2,3,5

¹Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States, ²Imaging Research Centre, St. Joseph’s Healthcare Hamilton, Hamilton, ON, Canada, ³Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁴Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ⁵Department of Medicine, McMaster University, Hamilton, ON, Canada

Free-breathing ¹H MRI–derived specific ventilation (SV) provides a way to visualize regional ventilation, which has been shown to be reduced in asthmatics compared to healthy volunteers. We hypothesized that free breathing MRI–derived SV in severe asthmatics would be sensitive to airway bronchodilation and airway dysfunction, and hence our objective was to measure SV using ¹H MRI in healthy volunteers and severe asthmatics pre- and post-bronchodilator and to evaluate the relationship with airway oscillometry measurements. Preliminary results in severe-asthmatics showed that free-breathing ¹H MRI–derived SV is sensitive to bronchodilator therapy and may reflect regional small airway pathology.

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