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Abstract #2309

Free breathing 1H MRI Specific Ventilation: Sensitivity to Bronchodilator and Airway Dysfunction in Severe Asthma

Dante PI Capaldi1, Norman B Konyer2, Melanie Kjarsgaard3, Michael D Noseworthy2,4, Parameswaran Nair3,5, and Sarah Svenningsen2,3,5
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States, 2Imaging Research Centre, St. Joseph’s Healthcare Hamilton, Hamilton, ON, Canada, 3Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 4Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 5Department of Medicine, McMaster University, Hamilton, ON, Canada

Free-breathing 1H MRI–derived specific ventilation (SV) provides a way to visualize regional ventilation, which has been shown to be reduced in asthmatics compared to healthy volunteers. We hypothesized that free breathing MRI–derived SV in severe asthmatics would be sensitive to airway bronchodilation and airway dysfunction, and hence our objective was to measure SV using 1H MRI in healthy volunteers and severe asthmatics pre- and post-bronchodilator and to evaluate the relationship with airway oscillometry measurements. Preliminary results in severe-asthmatics showed that free-breathing 1H MRI–derived SV is sensitive to bronchodilator therapy and may reflect regional small airway pathology.

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