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Abstract #2322

Inter-reader variability in Breast MRI Radiomics

Michael James Fox1, Roberto Lo Gullo2, Isaac Daimiel Naranjo2, Carolina Saccarelli2, Almir Bitencourt2, Katja Pinker-Domenig2,3, and Peter Gibbs2
1Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria

The purpose of this study was to investigate the effect of choice of radiologist on radiomics in breast MRI. Two cohorts of 100 patients each had breast lesions segmented by 4 independent radiologists, and these segmented images used to produce 101 radiomic features. over 90% of all features were found to have good or excellent agreement across readers, and a similar number of highly significant U-test were found for all readers. Differences between reader interpretation exist, however, they would not appear to effect the ability to distinguish between benign or malignant lesions.

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