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Abstract #2334

Pre-surgical evaluation of residual cancer  by breast MRI after neoadjuvant systemic treatment with High-resolution Diffusion Weighted Imaging

Rie Ota1, Masako Kataoka1, Maya Honda1, Ayami Ohno Kishimoto1, Akane Ohashi1, Mami Iima1, Kanae Miyake Kawai1, Tatsuki R Kataoka2, Masakazu Toi3, and Kaori Togashi1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University graduate school of medicine, Kyoto, Japan, 2Department of Pathology, Kyoto University Hospital, Kyoto, Japan, 3Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan

We aimed to investigate the accuracy of high resolution-DWI (HR-DWI) using rs-EPI in estimating residual lesion size after neoadjuvant systemic treatment (NST) using pathological information as a reference. Diagnosis of pCR by two readers were accurate in 83/79 % with HR-DWI, while 50/46 % on HR-CE MRI. Spearman’s correlation coefficient between size on pathology and that on HR-DWI were 0.79 (p<0.0001), indicating strong correlations. Spearman’s correlation coefficient between size on pathology and that on HR-CE-MRI were 0.68 (p<0.0001). Using HR-DWI, residual lesions were depicted with good agreement with the pathology without using contrast agent.

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