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Abstract #2347

The Impact of Acquisition Parameters on Alveolar Septal Wall Thickness Measurements with Hyperpolarized Xenon-129 MRI

Kai Ruppert1, Faraz Amzajerdian1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina S. Achekzai1, Ryan J. Baron1, Ian F. Duncan1, Harrilla Profka1, Yiwen Qian1, Mehrdad Pourfathi1, Federico Sertic1, Stephen Kadlecek1, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelhia, PA, United States

Measurements of the apparent alveolar septal wall thickness (SWT) with hyperpolarized xenon-129 (HXe) MRI are sensitive to inflammatory or fibrotic pathologies in the lung parenchyma but are also affected by lung inflation level. Here, we investigated the dependence of such measurements on the choice of acquisition parameters in a rabbit model. We found the SWT measurements to be strongly affected by the imaging parameters: in particular, the number and flip angle of the applied RF pulses centered at the dissolved-phase resonances. If this bias is minimized, the previously reported dependence of septal thickness measurements on lung inflation disappears.

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