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Abstract #2352

Feasibility of 3D flow-volume loop analysis using phase-resolved functional lung imaging (PREFUL) in comparison with 2D PREFUL

Filip KlimeŇ°1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Robert Grimm3, Cristian Crisosto1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hanover Medical School, Hanover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany

The measurement of ventilation dynamics with 2D proton MRI (PREFUL) might offer a sensitive lung function test but lacks a high spatial resolution and whole-lung acquisition is time consuming. Recently, the feasibility of 3D PREFUL was demonstrated. In this work, ventilation dynamics assessment using flow-volume loop (FVL) analysis is performed on 2D and 3D data of a healthy volunteer and an asthma patient. Full respiratory cycle was reconstructed to calculate regional ventilation and cross-correlation metric of FVL. Similar results suggest that 3D PREFUL might be an interesting alternative to 2D PREFUL due to its improved spatial resolution and acquisition efficiency.

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