Abstract #2352

Feasibility of 3D flow-volume loop analysis using phase-resolved functional lung imaging (PREFUL) in comparison with 2D PREFUL

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Robert Grimm³, Cristian Crisosto^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hanover Medical School, Hanover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany

The measurement of ventilation dynamics with 2D proton MRI (PREFUL) might offer a sensitive lung function test but lacks a high spatial resolution and whole-lung acquisition is time consuming. Recently, the feasibility of 3D PREFUL was demonstrated. In this work, ventilation dynamics assessment using flow-volume loop (FVL) analysis is performed on 2D and 3D data of a healthy volunteer and an asthma patient. Full respiratory cycle was reconstructed to calculate regional ventilation and cross-correlation metric of FVL. Similar results suggest that 3D PREFUL might be an interesting alternative to 2D PREFUL due to its improved spatial resolution and acquisition efficiency.

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