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Abstract #2359

Same-day reproducibility of quantitative lung perfusion metrics in patients with IPF

Paul J.C. Hughes 1, Nicholas D. Weatherley1, Helen Marshall1, Stephen M. Bianchi2, and Jim M. Wild1,3
1POLARIS, Department of Infection, Immunity and Cardiovascular Disease,, The University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals Foundation Trust, Academic Directorate of Respiratory Medicine, Sheffield, United Kingdom, 3Insigneo Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom

Recent work in assessing patients with idiopathic pulmonary fibrosis suggests that vascular changes, as assessed by dynamic contrast enhanced lung MRI, are a useful marker to assess disease progression. Therefore this work aimed to develop an image processing pipeline to assess same-day intra-participant reproducibility of quantitative perfusion metrics in a cohort of patients with idiopathic pulmonary fibrosis. From the data here it suggests that these quantitative metrics are not reproducible, even when patients are scanned on the same day.

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