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Abstract #2371

Assessment of interstitial membrane permeability using a generalized model of 129Xe septal uptake in the lung

Agilo L. Kern1,2, Karen M. Olsson2,3, Till F. Kaireit1,2, Frank K. Wacker1,2, Jens M. Hohlfeld2,3,4, Marius M. Hoeper2,3, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, 4Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

The hyperpolarized 129Xe chemical shift saturation recovery (CSSR) method combined with mathematical models of gas uptake provides unique insights into lung microstructure and function. Here, we propose a generalization of the Patz model for assessing interstitial membrane permeability. We test the model’s potential for in-vivo determination of membrane permeability by fitting to CSSR data from healthy volunteers and pulmonary hypertension (PH) patients. The obtained permeabilities lie between those estimated for O2 and CO2 in healthy volunteers and tend to be lower in PH. The proposed model enables the non-invasive assessment of interstitial barrier permeability and shows potential as diagnostic tool.

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