Abstract #2376

Multi-nuclear MRI to disentangle intracellular sodium concentration and extracellular volume fraction in breast

Carlotta Ianniello^1,2, Ryan Brown^1,2, Linda Moy^1,2, and Guillaume Madelin^1,2

¹Radiology, Center for Advanced Imaging Innovation and Research (CAI2R) and Center for Biomedical Imaging, New York University School of Medicine, NEW YORK, NY, United States, ²The Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, NEW YORK, NY, United States

The intracellular sodium concentration (C_IC) and extracellular volume fraction (ECV) are promising biomarkers in breast lesions. However, separating the contribution of the intracellular (IC) and extracellular (EC) compartments only relying on differences in ²³Na relaxation properties is challenging due to close similarity between the two compartments and the inability to measure IC and EC relaxation times in vivo. In this study we demonstrate the feasibility to quantify C_IC and ECV in three healthy subjects by using complementary information from ²³Na and ¹H MRI measurements. The mean C_IC and ECV between three healthy subjects were 27.7±4.1 mM and 0.29±0.07, respectively.

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