Using LI-RADS v2018 on MRI, LR-2, LR-3 and LR-4 lesions in cirrhosis have different natural outcomes, LI-RADS lesions demonstrate increasing risk of progression to HCC with increasing category. About two-fifths of LR-4 observations progressed to a malignant category. LR-3 observations with APHE or threshold/subthreshold growth upgraded to LR-5 were significantly higher. Most LR-2 observations that remain stable in category for at least a year.
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