Clinical data on the course of sub-centimeter-sized nodules (SCSNs) detected during surveillance for HCC is limited. Through this study we wished to evaluate arterially enhancing SCSN evolving into HCC. We tried identify specific size cut off, rate of growth, enhancement features which can predict which SCSN will turn into HCC. 47.5% of SCSN have the potential to turn into HCC. 8.55 mm is the optimal size cut off above which risk of developing HCC increases with a sensitivity of 71.4%. Diffusion restriction was seen in 50% and non uptake of hepatobiliary contrast in 91% of SCSN which developed into HCC.