Abstract #2452

A Deuterated 13C-Urea Reference to Eliminate 1H Imaging Artifacts in Hyperpolarized 13C MRI Studies

Collin J. Harlan¹, Zhan Xu ¹, Keith A. Michel^1,2, Christopher M. Walker¹, Sanjaya D. Lokugama³, Mark D. Pagel^2,3, and James A. Bankson^1,2

¹Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, United States, ³Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Multiparametric and hyperpolarized (HP) ¹³C Magnetic Resonance Imaging (MRI) are attractive multi-modality methods for prostate cancer imaging studies because of their non-invasiveness and characterization of changes in tumor metabolism. A ¹³C-urea calibration reference is required when conducting HP ¹³C MRI studies, which must be heavily doped with Gd⁺ to facilitate rapid calibrations. Care must be taken to ensure that the highly relaxed ¹H signal does not compromise DCE-MRI via hyperintense imaging artifacts. Deuteration and lyophilization of ¹³C-urea can be useful in creating a calibration reference that does not lead to imaging artifacts in ¹H Images.

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