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Abstract #2452

A Deuterated 13C-Urea Reference to Eliminate 1H Imaging Artifacts in Hyperpolarized 13C MRI Studies

Collin J. Harlan1, Zhan Xu 1, Keith A. Michel1,2, Christopher M. Walker1, Sanjaya D. Lokugama3, Mark D. Pagel2,3, and James A. Bankson1,2
1Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, United States, 3Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Multiparametric and hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) are attractive multi-modality methods for prostate cancer imaging studies because of their non-invasiveness and characterization of changes in tumor metabolism. A 13C-urea calibration reference is required when conducting HP 13C MRI studies, which must be heavily doped with Gd+ to facilitate rapid calibrations. Care must be taken to ensure that the highly relaxed 1H signal does not compromise DCE-MRI via hyperintense imaging artifacts. Deuteration and lyophilization of 13C-urea can be useful in creating a calibration reference that does not lead to imaging artifacts in 1H Images.

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