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Abstract #2469

Early Effect of 90Y locoregional therapy on tumor and liver parenchyma stiffness measured with MR elastography: initial experience  

Paul Kennedy1,2, Sara Lewis3, Octavia Bane1,2, Stefanie Hectors1,2,4, Edward Kim5, and Bachir Taouli1,2
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Radiology, Icahn School of Medicine at Mount Sinai, NY, NY, United States, 4Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 5Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, NY, NY, United States

In this study we assess early changes following 90Y radioembolization (RE) in hepatocellular carcinoma and liver parenchyma using MR elastography and predict response at 6 weeks/6 months. Tumor stiffness (TS) and liver stiffness (LS) adjacent to the tumor were significantly increased 6w following RE. Baseline TS and LS adjacent to the tumor were significantly lower in patients who achieved complete response. Baseline TS correlated with necrosis at 6w and was a significant predictor of partial response or stable disease based on mRECIST criteria following RE. MR elastography may be a useful tool for predicting necrosis and tumor response to RE.

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