Abstract #2469

Early Effect of 90Y locoregional therapy on tumor and liver parenchyma stiffness measured with MR elastography: initial experience

Paul Kennedy^1,2, Sara Lewis³, Octavia Bane^1,2, Stefanie Hectors^1,2,4, Edward Kim⁵, and Bachir Taouli^1,2

¹BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Radiology, Icahn School of Medicine at Mount Sinai, NY, NY, United States, ⁴Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ⁵Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, NY, NY, United States

In this study we assess early changes following ⁹⁰Y radioembolization (RE) in hepatocellular carcinoma and liver parenchyma using MR elastography and predict response at 6 weeks/6 months. Tumor stiffness (TS) and liver stiffness (LS) adjacent to the tumor were significantly increased 6w following RE. Baseline TS and LS adjacent to the tumor were significantly lower in patients who achieved complete response. Baseline TS correlated with necrosis at 6w and was a significant predictor of partial response or stable disease based on mRECIST criteria following RE. MR elastography may be a useful tool for predicting necrosis and tumor response to RE.

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