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Abstract #2485

Evaluation of liver function using the hepatocyte fraction based on gadoxetic acid–enhanced MR imaging

Mao-Tong LIU1, Xue-Qin ZHANG1, Jian LU1, and Wei-Bo CHEN2
1Third Affiliated Hospital of Nantong University & Nantong Third People's Hospital, Nan Tong, China, 2Philips Healthcare Shanghai, China, Shang Hai, China

The purpose of this study was to evaluate the feasibility of using the hepatocyte fraction based on gadoxetic acid–enhanced MRI for the assessment of liver function. Firstly, T1 mapping imaging was performed before and 20 minutes after Gd-EOB-DTPA administration, The following parameters are then obtained from the images: pre- and postcontrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (Δ R1), rate of the decrease of the T1 relaxation time (Δ T1), hepatocyte fraction (HeF), and uptake coefficient (K). Our study showed that hepatocyte fraction is an effective method to evaluate liver function in patients with hepatitis B cirrhosis.

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