Abstract #2511

MRI Relaxometry: Pancreatic R2* Values in Relation to Hepatic and Splenic R2* with Respect to Transfusion Frequency

Arthur Peter Wunderlich^1,2, Stephan Kannengießer³, Lena Kneller¹, Berthold Kiefer³, Holger Cario⁴, Meinrad Beer¹, and Stefan Andreas Schmidt¹

¹Dept. for Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, ²Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Dept. for Pediatric and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

To study pancreatic iron accumulation in liver overloaded patients in relation to hepatic and splenic iron content, 90 patients were investigated at 1.5 T MRI with a prototype breath hold volumetric 3D GRE sequence with in-line R2* calculation. Mean R2* values were determined in liver, spleen and pancreas by manually drawn ROIs. Pancreatic R2* values were related to hepatic and splenic R2* by multiple linear regression, yielding significant correlation in two subgroups: a) frequently transfused patients, and b) regular transfused patients. Correlation, and therefore, ability to predict pancreatic R2*, improved by including splenic R2* compared to solely hepatic R2*.

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