It is challenging to differentiate between uterine submucous myoma and endometrial polyps, due to a high similarity of their manifestations in conventional MRI. Meanwhile, T2 mapping is an objective and stable technique which has been applied to diagnosis of many diseases. Here we evaluate the value of quantitative measurements derived from T2 mapping and DWI in differentiating between uterine submucous myoma and polyps. We found a descending order of T2 values from healthy endometrium, endometrial polyp to submucous myoma group. We concluded that T2 mapping can be used as a quantitative tool in the differentiation between submucous myoma and polyps.