Abstract #2532

Placental Perfusion Imaging on Zika-Infected Rhesus Macaques using Velocity-Selective ASL MRI

Ruiming Chen¹, Sydney Nguyen^2,3,4, Kai D. Ludwig¹, Daniel Seiter¹, Megan E. Murphy^2,3,4, Kathleen M. Anthony^2,3,4, Terry K. Morgan⁵, Ante Zhu^6,7, Dahan Kim¹, Sean B. Fain^1,6,7, Oliver Wieben^1,6, Thaddeus G. Golos^2,3,4, and Kevin M. Johnson^1,6

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ³Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Pathology, Oregon Health & Science University, Portland, OR, United States, ⁶Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Effective non-invasive assessment of placental health, particularly in early pregnancy, is of clinical interest but currently lacking. Arterial spin labeling (ASL) MRI can safely provide local functional assessment of placental perfusion, however, placental perfusion imaging is challenging and current approaches have shortcomings. Here we investigate a multi-slice velocity-selective (VS ASL) sequence with volumetric placental perfusion assessment and report on local and global perfusion across multiple gestational stages for zika-infected rhesus macaques and healthy controls.

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