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Abstract #2532

Placental Perfusion Imaging on Zika-Infected Rhesus Macaques using Velocity-Selective ASL MRI

Ruiming Chen1, Sydney Nguyen2,3,4, Kai D. Ludwig1, Daniel Seiter1, Megan E. Murphy2,3,4, Kathleen M. Anthony2,3,4, Terry K. Morgan5, Ante Zhu6,7, Dahan Kim1, Sean B. Fain1,6,7, Oliver Wieben1,6, Thaddeus G. Golos2,3,4, and Kevin M. Johnson1,6
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, 3Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, 4Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 5Pathology, Oregon Health & Science University, Portland, OR, United States, 6Radiology, University of Wisconsin - Madison, Madison, WI, United States, 7Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Effective non-invasive assessment of placental health, particularly in early pregnancy, is of clinical interest but currently lacking. Arterial spin labeling (ASL) MRI can safely provide local functional assessment of placental perfusion, however, placental perfusion imaging is challenging and current approaches have shortcomings. Here we investigate a multi-slice velocity-selective (VS ASL) sequence with volumetric placental perfusion assessment and report on local and global perfusion across multiple gestational stages for zika-infected rhesus macaques and healthy controls.

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