Abstract #2542

Is Liver Function Affected by Resective Surgery? – Hepatocyte Uptake and Efflux to Bile in Liver Cancer Determined Using Gadoxetate Enhanced MRI

Christian Simonsson^1,2, Markus Karlsson^1,3, Bengt Norén¹, Gunnar Cedersund², Per Sandström⁴, Anna Lindhoff Larsson⁴, Nils Dahlström^1,3, and Peter Lundberg^1,3

¹Departments of Radiation Physics, Radiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Department of Medical Engineering, Linköping University,, Linköping Univeristy, Linköping, Sweden, ³Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, ⁴Department of Surgery, Department of Clinical and Experimental Medicin, Linköping University, Linköping, Sweden

Just after surgery there is a period were the remnant tissue needs to match the requirement of normal liver function while recovering. This could lead to fatal consequences after too extensive surgical procedures, or due to insufficient liver function. In contrast, it might also be the case that the surgical procedure is too conservative because the predicted liver function is underestimated. This would not have been the case if it was possible to use more precise measures of liver function. We investigated the capabilities of gadoxetate enhanced MRI for determining liver function pre- and post-surgery using two separate approaches.

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