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Abstract #2566

Shape and Volume Analysis of the Fetal Brain Pre and Post Fetal Spina Bifida Surgery

Nada Mufti1,2,3, Michael Ebner2,3, Lucas Fidon2, Dimitra Flouri2,3, Riine Heinsalu2, Tom Vercauteren2,4, Sebastien Ourselin2, Luc De Catte4, Jan Deprest1,4, Anna L David1,4, Philippe Demaerel5, Andrew Melbourne2,3, and Michael Aertsen5
1Institute for Women's Health and Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 2School of Biomedical Engineering and Imaging Sciences (BMEIS), King's College London, London, United Kingdom, 3Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 4Department of Obstetrics and Gynaecology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, 5Department of Radiology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium

Thorough assessment of the fetal central nervous system is required to select the most suitable candidates for fetal spina bifida surgery, and for post-operative monitoring to predict outcome. Children with myelomeningocele exhibit difficulties in cognitive performance, and motor skills1. This is related to the Chari II malformation and ventriculomegaly2,3. Our aim is to determine if MRI technology can quantify volume, surface area, and shape of cerebral structures before and after fetal spina bifida surgery. We explore if these parameters can be used as potential biomarkers for efficacy of fetal surgery by correlating with herniation level.

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