Abstract #2566

Shape and Volume Analysis of the Fetal Brain Pre and Post Fetal Spina Bifida Surgery

Nada Mufti^1,2,3, Michael Ebner^2,3, Lucas Fidon², Dimitra Flouri^2,3, Riine Heinsalu², Tom Vercauteren^2,4, Sebastien Ourselin², Luc De Catte⁴, Jan Deprest^1,4, Anna L David^1,4, Philippe Demaerel⁵, Andrew Melbourne^2,3, and Michael Aertsen⁵

¹Institute for Women's Health and Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ²School of Biomedical Engineering and Imaging Sciences (BMEIS), King's College London, London, United Kingdom, ³Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ⁴Department of Obstetrics and Gynaecology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, ⁵Department of Radiology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium

Thorough assessment of the fetal central nervous system is required to select the most suitable candidates for fetal spina bifida surgery, and for post-operative monitoring to predict outcome. Children with myelomeningocele exhibit difficulties in cognitive performance, and motor skills¹. This is related to the Chari II malformation and ventriculomegaly^2,3. Our aim is to determine if MRI technology can quantify volume, surface area, and shape of cerebral structures before and after fetal spina bifida surgery. We explore if these parameters can be used as potential biomarkers for efficacy of fetal surgery by correlating with herniation level.

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