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Abstract #2570

Quantification of T2* relaxation times of human liver in the midtrimester fetus at 1.5T

Matthias R Muehler1, Ante Zhu1,2, Oliver Wieben1,2,3, Diego Hernando1,2,3,4, Dinesh Shah5, and Scott B. Reeder1,2,3,6,7
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 4Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, 5Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, 6Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Medicine, University of Wisconsin-Madison, Madison, WI, United States

In preeclampsia, the erythropoetin level in the fetus has been reported to be moderately elevated and the number of erythroid cells in the fetal liver reduced. Assessment of fetal liver health and function over gestation, including hepatic hematopoiesis, is of great interest. T2* relaxometry is an emerging quantitative biomarker of liver iron content. In this study, we assessed fetal liver T2* in the midtrimester pregnancy. A fetal liver T2* of 22ms and 25ms at 14 and 20 weeks of gestation, respectively, was observed at 1.5T. T2* values are significantly correlated with gestational age but not with obesity or mothers’ age.

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