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Abstract #2572

Longitudinal Study of T2*-based BOLD Placental MRI in Obese Pregnant Human Subjects

Ante Zhu1,2, Jitka Starekova2, Tom Batan3, Kevin Johnson2,4, Scott B. Reeder1,2,4,5,6, Oliver Wieben1,2,4, Dinesh Shah7, and Diego Hernando1,2,4,8
1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Integrative Biology, University of Wisconsin-Madison, Madison, WI, United States, 4Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, 6Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, 8Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States

Maternal obesity is associated with increased risk of gestational hypertension, preeclampsia and fetal growth restriction, complications related to reduced uteroplacental blood flow and placental vascularity malformation. T2* measurements of blood oxygen level-dependent effects have promise for assessing placental function. Here, we measured placental T2* in non-obese and obese pregnant women at 14 and 20 weeks of gestation. Our study showed that the range of placental T2* is similar between the two populations at both gestation ages. Trends of decreased and increased placental T2* with gestation were observed in different subjects, suggesting longitudinal changes in placental T2* may vary among subjects.

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