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Abstract #2580

Hyoscine butylbromide for bowel movement reduction in mouse abdominal MRI

Carlos Bilreiro1, Francisca F. Fernandes1, Rui V. Simões1, Celso Matos1, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal

Bowel movement is a source of motion artifacts in mouse abdominal MRI. This work aimed to evaluate fasting and hyoscine butilbromide (Buscopan®) for its reduction. Thirteen mice were imaged in a 9.4T MRI scanner with a FLASH sequence for 90 minutes (~19s temporal resolution): 6 were injected with a Buscopan® bolus, 4 with a bolus and constant infusion, and 3 were food deprived. A single bolus of Buscopan® was effective for bowel movement reduction in mice, for up to 1h, whereas other methods were not effective. These data favor the use of Buscopan® for abdominal MRI in the mouse.

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