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Abstract #2582

Imaging of the intestinal lymphatics following oral consumption of lipids using MRI.

Hannah Grace Williams1, Adelaide Jewell2, Caroline Hoad1,3, Luca Marciani3,4, Snow Stolnik-Trenkic2, Pavel Gershkovich2, and Penny Gowland1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2School of Pharmacy, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre, Nottingham University Hospital and University of Nottingham, Nottingham, United Kingdom, 4Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

It has been shown previously that lipophilic (lipid soluble) drugs administered in lipid-based formulations (or using lipophilic prodrugs) can be delivered in very high concentrations to the intestinal lymphatics. In order for the intestinal lymphatic targeting to be clinically relevant, the response of intestinal lymph following oral administration of lipids needs to be investigated in humans. This is the first study we are aware of using MRI to study changes in lymph nodes following the consumption of a fatty meal. With optimisation this method could provide a novel marker of which nodes could be target for treatment using lipophilic drugs.

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