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Abstract #2588

Serial Imaging of Splenomegaly in the Sleeping Sickness Infected Mouse

Samantha Paterson1, William Holmes1, Linda Carberry1, and Jean Rodgers1
1University of Glasgow, Glasgow, United Kingdom

Splenomegaly is a symptom of the African parasitic disease, sleeping sickness. This study is the first research to demonstrate splenomegaly non-invasively in a murine model of sleeping sickness. This researched showed an increase in the size of the spleen of over 20 times the healthy volume during the late stage of the disease whilst also demonstrating a change in the rate of increase during different stages of the disease. Overall, new information about splenomegaly in sleeping sickness has been demonstrated for the first time.

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