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Abstract #2591

Detection of Active Brown Adipose Tissue Using Quantitative Susceptibility Mapping (QSM)

Cuiling Zhu1, Yihao Guo2, Wenbin Si2, Yingjie Mei3, Qiaoling Zhong1, Lijie Zhong1, Yanqiu Feng2, and Xiaodong Zhang1
1Department of Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 2School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 3Philips Healthcare, Guangzhou, China

Activated and inactivated brown adipose tissue showed some differences in function, protein expression and intracellular components, which remained non-invasive MRI testing possible. Despite its strong relevance with iron contents, QSM detect BAT in large lipid depots remains a major challenge. This work proposes a method that use values of QSM and (fat fraction) FF to quantitatively distinguish the two groups in brown adipose tissue depot in vivo, histological validation is then performed. Preliminary results are broadly in line with expectation.

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