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Abstract #2599

Characterization of NAFLD disease evolution with multiparametric MRI/MRE and multi-state Hidden Markov Model

Jingbiao Chen1,2, Yunyi Kang3, Feng Ju3, Jiahui Li1, Jie Chen1, Xin Lu1, Richard L Ehman1, Vijay H Shah2, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, United States

Non-invasively diagnosing non-alcoholic fatty liver disease (NAFLD) and predicting disease prognosis in individual patients are two main unmet clinical needs. There are very few longitudinal studies that evaluate imaging, biochemical, and histopathological variables that predict disease progression of NAFLD. This study established a multi-state Hidden Markov model (HMM) of NAFLD evolution in an animal model with three imaging biomarkers: MRI derived proton density fat fraction (PDFF) and MR elastography (MRE) assessed liver stiffness (LS) and loss modulus (LM). Results have shown that a 3-state HMM can well characterize the natural history of NAFLD, and predict disease progression or regression.

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