Abstract #2621

Flow quantification with navigator-gated 4D flow MRI in portal hypertension

Octavia Bane^1,2, Daniel Stocker^1,2, Paul Kennedy^1,2, Stefanie Hectors^1,2,3, Susanne Schnell⁴, Scott Friedman⁵, Thomas Schiano⁵, Isabel M Fiel⁶, Swan Thung⁶, Aaron Fischman², Michael Markl^4,7, and Bachir Taouli^1,2

¹BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ⁴Department of Radiology, Northwestern University, Chicago, IL, United States, ⁵Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁷Biomedical Engineering, Northwestern University McCormick School of Engineering, Evanston, IL, United States

The purpose of our prospective study was to correlate the hepatic vasculature hemodynamic parameters measured with navigator-gated 4D flow MRI with the hepatic venous pressure gradient (HVPG) in patients with chronic liver disease and suspicion of portal hypertension (PH). Peak velocity in the celiac trunk (CT) was moderately correlated with HVPG, and was significantly elevated in patients with PH. CT flow was significantly elevated in patients with clinically significant PH (CSPH), while portal vein peak velocity was significantly reduced in patients with cirrhosis. Our results suggest that 4D flow MRI may be sensitive to hemodynamic changes in patients with PH.

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