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Abstract #2623

Post-treatment recovery of perfusion-related diffusion in the fatty liver of type 2 diabetes mellitus: an IVIM-DWI study

Wei Wei1, Yan Bai1, Xianchang Zhang2, Robert Grimm3, and Meiyun Wang1
1Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd, Beijing, China, 3MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany

This study aimed to investigate the utility of intra-voxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for monitoring the liver function change during type 2 diabetes mellitus (T2DM) treatment. The results showed that liver fat fractions were significantly decreased and perfusion-related diffusion (D*) was significantly increased, but pure molecular diffusion (D) values showed no significant change in T2DM patients after treatment for three months. Our findings indicated that improvement of hepatic parenchymal perfusion may occur earlier than water molecule diffusion during T2DM treatment. D* may be a more sensitive biomarker than D to characterize the liver function change during T2DM treatment.

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