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Abstract #2636

Travelling kidneys: Multicentre multivendor variability of renal BOLD and T1 mapping – preliminary results

Charlotte E Buchanan1, Fabio Nery2, Andrew Priest3, Eleanor F Cox1, Joao Sousa4, Michael Nation5, Iosif Mendichovszky3, Steven Sourbron6, David Thomas2,7, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Developmental Imaging and Biophysics Section, University College London, London, United Kingdom, 3Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 4Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 5Kidney Research UK, Peterborough, United Kingdom, 6Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 7Queen Square Institute of Neurology, University College London, London, United Kingdom

We have performed an intra-individual, inter-vendor comparison of renal T1 and BOLD T2* measures using predominantly product sequences. Renal T2* is sensitive to dephasing due to background magnetic field gradients, the degree of which differs across the MR vendors. A strong B0 L-R gradient, especially prominent for one vendor, leads to an asymmetry in T2* values between kidneys. B1 maps vary across subjects with no vendor-specific bias. Renal cortex T1 values computed using a 2-parameter fit were shown to systematically vary across vendors; a 3-parameter fit reduced this bias but differences remain. This highlights areas of future development for standardisation.

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