Meeting Banner
Abstract #2679

Differentiating ALTs/DDLs from benign lipomas using high-resolution 1H MR Spectroscopy

Santosh K Bharti1, Brett A. Shannon2, Raj Kumar Sharma1, Adam Levin2, Carol Morris2, Laura Fayad2,3, and Zaver M. Bhujwalla1,4,5
1Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine,, Baltimore, MD, United States, 2Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Musculoskeletal Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 53Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Adipocytic tumors present a spectrum of neoplastic disease including benign lipomas, atypical lipomatous tumors (ALTs), and malignant liposarcomas DDLs. Distinguishing high-grade liposarcomas (DDLs-dedifferentiated liposarcomas) and premalignant ALTs from benign lipomas can be a diagnostic challenge with implications for surgical and clinical management. Our study demonstrate that high-resolution 1H magnetic resonance spectroscopy (MRS) may be used as an additional method for classification and differential diagnosis of ALTs from benign lipomas. Metabolic analysis clearly reflects the metabolic changes associated with malignant progression.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here