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Abstract #2694

Dynamic Contrast Enhanced MR Imaging of Synovitis: Repeatability, Discriminative Validity and Responsiveness in Knee Osteoarthritis

James MacKay1,2, Faezeh Sanaei Nehad3, Josh Kaggie2, Jo Naish3, Caleb Roberts3, Martin Graves2, Fiona Gilbert2, Andrew McCaskie4, John Waterton3,5, Rob Janiczek6, Alexandra Roberts6, and Geoff Parker3
1Radiology, University of East Anglia, Norwich, United Kingdom, 2Radiology, University of Cambridge, Cambridge, United Kingdom, 3BiOxyDyn Ltd, Manchester, United Kingdom, 4Surgery, University of Cambridge, Cambridge, United Kingdom, 5Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom, 6Clinical Imaging, GlaxoSmithKline, Stevenage, United Kingdom

Synovitis is common in knee osteoarthritis (OA) and can be quantified using dynamic contrast-enhanced MR imaging (DCE-MRI). There is a strong rationale for therapeutic targeting of synovitis in OA, and imaging biomarkers derived from DCE-MRI may help evaluate response in clinical trials.

Here we evaluate the test-retest repeatability, ability to discriminate between OA (n = 14) and age-matched controls (n = 6) and 6-month responsiveness to change of three DCE-MRI biomarkers: Ktrans, IAUCĀ­60, and synovial tissue volume.

Ktrans demonstrated the best repeatability, discrimination and sensitivity to change suggesting that it is the optimal DCE-MRI biomarker for use in clinical trials.

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