Abstract #2705

31P MRS assessments of mitochondrial dysfunction in patients with peripheral arterial disease undergoing revascularization.

Jabrane Karkouri^1,2,3, Jill Slade⁴, Helene Ratiney¹, Sylvain Grange¹, Anne Tonson⁴, Pierre Croisille¹, and Magalie Viallon¹

¹Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, Lyon, France, ²SIemens Healthcare SAS, Saint-Denis, France, ³Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, ⁴Radiology, Michigan state university, East Lansing, MI, United States

Obliterative arterial disease of the lower limbs is a disease that obstructs lower extremities arteries, resulting in reduced lower limb perfusion and possibly mitochondrial dysfunction. Mitochondrial function of the calf assessed via 31P MRS at moderate and low exercise intensities before and after revascularization and phase contrast angiography of the posterior tibial artery enabled the assessment of vascular and mitochondrial contributions of the patients.

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